Position Overview/Department Description

The Genomic Medicine Unit (GMU) CMC group at Sanofi is dedicated to the establishment of best-in-class manufacturing platforms to support development of life-changing advanced cell and gene therapy products, including recombinant AAV vectors, lentiviral vectors and cell therapy products. Sanofi is looking for an experienced expression platform development professional with experience in viral vector production to join the Genomic Medicine Predevelopment expression platform development located in Waltham, MA in the role of Senior Scientist. The Expression Platform Development team within Sanofi GMU Predevelopment operates with the mission to develop innovative expression vectors and host cell lines for Sanofi’s genomic medicine viral vector production platforms.

We are looking for highly motivated candidates with knowledge of viral vector production platforms and experience in optimization of biologics production through expression vector or host cell line engineering.

The successful applicant will make critical contributions to the development and optimization of GMU CMC’s next generation AAV production platform by working with the expression platform team and other members of Predevelopment, by leveraging their extensive scientific knowledge and hands-on experiences with mammalian expression systems, and through meticulous analytical and critical thinking skills and strong communication capabilities.

Key Responsibilities

• Independently design, conduct and document molecular biology, cell culture, cell engineering studies to evaluate, develop and establish disruptive and innovative technologies to improve AAV production platforms.

• Establish and drive innovation in furthering scientific and process understanding to enhance viral vector productivity and quality.

• Present findings/results at internal meetings including team meetings, cross functional meetings and external conferences.

• Contribute to the drafting of manuscripts and patent applications

• Mentor junior staff as needed

• Occasional weekend/holiday work to support ongoing lab activities

Basic Qualifications

• PhD degree in Molecular and Cell Biology, Biochemistry, Virology or related discipline with a minimum of 4 years of relevant experience or a Master’s degree with a minimum of 8 years of experience or a Bachelor’s degree with a minimum of 10 years of experience.

• Excellent oral and written communication skills

Preferred Qualifications

• Comprehensive understanding of AAV biology and interplay with helper viruses and the host cell.

• Experience in the biotech/pharmaceutical industry with an excellent understanding of the theory and practice of optimizing and engineering mammalian cells for bioproduction.

• Experience in synthetic biology.

• Experience in inducible expression systems for mammalian gene expression.

• Experience in the development of HeLa-based producer cell lines and/or HEK AAV transient transfection production platforms.

At Sanofi R&D North America, we deliver meaningful solutions for patients. We transform science into breakthrough, best-in-class and first-in-class medicines and vaccines. We believe in creating a diverse and inclusive workforce – and workplace – which brings together the collective brainpower of over 2,000 colleagues and provides you with an exciting place to grow and develop. We set the bar high, and we deliver. Join us and together we will build on our trusted legacy of breakthroughs for society.

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

As a healthcare company and a vaccine manufacturer, Sanofi has an important responsibility to protect individual and public health. All US based roles require individuals to be fully vaccinated against COVID-19 as part of your job responsibilities.

According to the CDC, an individual is considered to be “fully vaccinated” fourteen (14) days after receiving (a) the second dose of the Moderna or Pfizer vaccine, or (b) the single dose of the J&J vaccine. Fully vaccinated, for new Sanofi employees, is to be fully vaccinated 14 DAYS PRIOR TO START DATE.

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At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.