Ionis Pharmaceuticals, Inc., is headquartered in Carlsbad, California, with offices in Boston, Massachusetts, and Dublin, Ireland. For more than 30 years, Ionis has been the leader in RNA-targeted therapy, pioneering new markets and changing standards of care with our novel antisense technology. Ionis currently has three marketed medicines and a premier late-stage pipeline highlighted by industry-leading cardiovascular and neurological franchises. Our scientific innovation began and continues with the knowledge that sick people depend on us, which fuels our vision to become the undisputed leader in genetic medicine, utilizing a multi-platform approach to discover, develop and deliver life-transforming therapies.

As the first company to fully harness the power of RNA technology for human therapeutics, Ionis’ platform continues to revolutionize drug discovery and transform lives for patients with unmet needs. We are building upon our innovative research and drug development excellence to provide greater value to patients, and we are well positioned financially to deliver on our strategic goals.

Ionis is a challenging, motivating and rewarding environment designed to foster innovation and scientific excellence. Our success is a direct result of our outstanding employees. We are interested in bringing together a diverse group of individuals with different skill sets and perspectives into this creative environment to be part of a productive and inclusive team. While acknowledging people are actively engaged in hybrid/remote work, we continue to invest time, money, and energy into making our workplace locations a place where our culture and employees can thrive. We believe engaging on a day-to-day basis, in person, builds solid and lasting relationships, and contributes positively to our culture and innovation. From the heart of our stunning Carlsbad campus, we aim to provide a central connection point for all our employees. These facilities give us the opportunity to connect cross-functionally, collaborate and to build on the success of our business as we continue to grow. Join us and experience our unique culture while you develop and expand your career.

DIRECTOR, MEDICAL EVIDENCE GENERATION

SUMMARY:

The Director of Medical Evidence Generation will be responsible for executing Ionis’ medical evidence generation strategy across cardiometabolic, neurology and rare disease therapeutic areas. This role will involve working closely with cross-functional teams including Medical Affairs, Clinical Development, HEOR, and Commercial teams to design and conduct epidemiology studies/analyses, observational research studies, develop disease and product registries, and design and implement Phase 4 studies. This role will report to the Executive Director of Medical Evidence Generation.

RESPONSIBILITIES:

• Design and execute evidence generation activities that will fill priority evidence gaps identified in asset-specific Integrated Evidence Generation Plans (IEGPs).
• Serve as the hub of epidemiology data for internal and external use, based on literature reviews, claims database analyses, or other epidemiological approaches/studies.
• Design and lead observational research studies to evaluate real-world effectiveness, safety, and other outcomes.
• Develop and maintain disease and product registries, including collaborative registries with academic institutions, patient advocacy groups, or other external organizations.
• Design and implement Phase 4 study designs, including observational studies, to generate additional medical evidence for marketed products.
• Apply causal inference expertise to ensure robust analysis of observational data to support evidence-based decision-making.
• Collaborate with cross-functional teams including Medical Affairs, Clinical Development, HEOR, and Commercial teams to ensure that medical evidence generation activities are aligned with the overall business objectives.
• Present medical evidence to internal and external stakeholders, including at scientific conferences, and other relevant forums.
• Stay up-to-date with the latest developments in epidemiology, observational research, registry methodologies, Phase 4 study design, and advanced analytical methods, and incorporate them in Ionis’ medical evidence generation activities.

QUALIFICATIONS:

• A PhD or Master’s degree in epidemiology, public health, or related field with at least 8 years of experience in the pharmaceutical industry.
• Extensive experience designing and leading observational research studies, including the use of real-world data.
• Demonstrated expertise in developing and maintaining disease and product registries.
• Strong knowledge of Phase 4 study design and implementation.
• Strong knowledge of causal inference methods, including propensity scores and instrumental variables.
• Strong analytical and problem-solving skills.
• Strong publication record.
• Excellent verbal and written communication and presentation skills.
• Ability to work collaboratively with cross-functional teams.
• Ability to work independently and manage multiple projects simultaneously.

If you are passionate about using medical evidence to improve health outcomes for patients and have appropriate qualifications, we encourage you to apply for this exciting opportunity.

Please visit our website, www.ionispharma.com for more information about Ionis and to apply for this position; reference requisition # IONIS003051

Ionis offers an excellent benefits package! Follow this link for more details: Ionis Benefits

Full Benefits Link: https://www.ionispharma.com/careers/working-at-ionis/#:~:text=our%20employee%20spotlight-,Benefits,-Employees%20are%20rewarded

The pay scale for this position is $230,723 to $263,391

NO PHONE CALLS PLEASE. PRINCIPALS ONLY.

Ionis Pharmaceuticals, Inc. and all its subsidiaries are proud to be EEO employers.