Some opportunities happen only once in a lifetime - like a job where you have the chance to change lives. At Alexion, people living with rare and devastating diseases are our Guiding Star. We are driven to continuously innovate and create meaningful value in all we do to help patients and families fully live their best lives. We value the uniqueness and diversity of our employees and recognize that nurturing the diverse perspectives and strengths of our people translates into innovative breakthroughs for patients.

This is what you will do:

We are recruiting for an Executive Director of Translational Medicine. This is an opportunity for a well-trained clinician with strong leadership skills who is driven by science and the desire to develop innovative therapies for rare diseases. This leader will report to the Vice President of Translational Science. The successful candidate will have a mastery of the drug development process, notably in early phase clinical trials, protocol writing, study conduct, data review and reconciliation, the principles of translational medicine, and what it takes to lead teams successfully. This role allows for growth and development while working in a collaborative, vibrant environment.

The candidate will be expected to understand our company's portfolio, and collaborate with discovery and translational research biologists, biomarkers, diagnostics, and clinical pharmacology scientists to envision meaningful target engagement, pharmacodynamic, and patient stratification biomarkers with potential line-of-site to companion diagnostics.

You will be responsible for:

• Leading a team of Clinical Development professionals, you will work directly with “Discovery” areas that include: neuroscience, cardiometabolic, hematology/renal, bone, and genomic medicine.
• Planning, implementing and managing the daily operation of assigned drug development projects.
• Participating in Research extended leadership teams.
• Collaborating effectively with key internal and external stakeholders
• Contributing to and supporting Department/Clinical initiatives to improve the quality and content of all clinical programs as well as the cross functional/organization processes designed to effectively deliver our R&D portfolio.

You will need to have:

• MD or MD/PhD
• Direct/Oversee the design and implementation of early-stage clinical projects, and lead our Early Global Program Teams (eGPT). Ensure that the overall scientific and medical content of all clinical programs is scientifically and clinically rigorous.
• Oversee early clinical development and biomarker plans that integrate pre-clinical and early clinical findings while working to ensure cross-functional alignment on an ongoing basis throughout the early phases of clinical development.
• Collaborate with Clinical Pharmacology to design scientifically rigorous and maximally cost-effective clinical protocols that are aligned with the clinical development plan.
• Present and defend protocols and clinical development plans at internal governance forums.
• Monitor study progress, ensure proper study conduct and adherence to the protocol, lead data review, evaluation, and analyses with support from Data Management and Stats & Programming team.
• Present study updates, interim results, and final headline data to senior management as required.
• Prepare various official and regulatory documents for Regulatory and other agencies, such as Dossiers, INDs, Safety and Annual reports, handling of responses to regulatory agencies regarding questions about complex clinical development issues (e.g., safety or efficacy).
• Lead cross-functional teams comprised of multidisciplinary professionals and clinical scientists. Direct responsibility for leading a team of Clinical Development professionals and ensure delivery of their portfolio of assets.
• Implement clinical R&D policies, SOPs and related directives.
• Review potential in-licensing candidates and present recommendations to Senior Management groups.
• Support any needed due diligence and prepare/present medically sound strategy and plans associated with advanced opportunities.
• Contribute and support Department/Clinical initiatives to improve the quality and content of all clinical programs as well as the cross functional/organization processes designed to effectively deliver our R&D portfolio.
• Clinical or research experience (in an academic or pharmaceutical environment) related to the design and/or conduct of clinical studies is required.
• The duties of this role are generally conducted in an office environment. As is typical of an office-based role, employees must be able, with or without an accommodation to: use a computer; engage in communications via phone, video, and electronic messaging; engage in problem solving and non-linear thought, analysis, and dialogue; collaborate with others; maintain general availability during standard business hours.

We would prefer for you to have:

• Specialty and sub-specialty training is preferred.

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Alexion is a global biopharmaceutical company focused on serving patients and families affected by rare diseases and devastating conditions through the discovery, development and commercialization of life-changing medicines. Headquartered in Boston, Massachusetts, Alexion has offices around the globe and serves patients in more than 50 countries. Further information about Alexion can be found at: www.alexion.com.

Alexion is proud to be an Equal Employment Opportunity and Affirmative Action employer. We are committed to fostering a culture of belonging where every single person can belong because of their uniqueness. The Company will not make decisions about employment, training, compensation, promotion, and other terms and conditions of employment based on race, color, religion, creed or lack thereof, sex, sexual orientation, age, ancestry, national origin, ethnicity, citizenship status, marital status, pregnancy, (including childbirth, breastfeeding, or related medical conditions), parental status (including adoption or surrogacy), military status, protected veteran status, disability, medical condition, gender identity or expression, genetic information, mental illness or other characteristics protected by law. Alexion has taken critical steps to protect colleagues, loved ones, and patients from COVID-19 and its variants. All US-based employees must comply with Alexion's COVID-19 vaccination mandate. Alexion provides exceptions based on applicable state law as well as reasonable accommodations to meet the needs of candidates and employees. To begin an interactive dialogue with Alexion regarding a legally required exemption or accommodation, please contact accommodations@Alexion.com. Alexion participates in E-Verify.

As a leading employer in our industry, Alexion offers a highly competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, 401(k) with company match, tuition reimbursement, and much more.

AstraZeneca completed its acquisition of Alexion, marking the creation of Alexion, AstraZeneca Rare Disease. If you're interested in career opportunities with AstraZeneca, click here.